In the not-too-distant future, Billy (Mark Duplass) and Ray (Sterling K. Brown) are lifelong best friends, brothers from another mother—they also happen to be the last two men on earth. Their survival is largely due to Ray, a brilliant scientist who designed the custom biosphere they call home, outfitting it with both creature comforts and the necessities to sustain life on a doomed planet. When the population of their fishpond—which supplies essential protein—begins waning, the men find themselves facing an ominous future. But life may yet find a way… Uproarious and tender in equal measure, this TIFF favorite and directorial debut from long-time Duplass producer Mel Eslyn explores the human capacity for change.